Jin Won Hyun Selected Research

ginsenoside M1

12/2013	Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity.
7/2013	The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
4/2013	20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells.
9/2010	Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase.
1/2010	Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells.
7/2009	Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo.

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Jin Won Hyun Research Topics

Disease

34	Neoplasms (Cancer) 01/2022 - 03/2002
23	Colonic Neoplasms (Colon Cancer) 09/2022 - 01/2010
13	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2009
12	Colorectal Neoplasms (Colorectal Cancer) 05/2022 - 04/2012
7	Body Weight (Weight, Body) 01/2016 - 02/2008
6	Leukemia 06/2016 - 07/2003
5	Lung Neoplasms (Lung Cancer) 07/2016 - 08/2005
5	Melanoma (Melanoma, Malignant) 05/2016 - 02/2013
4	Breast Neoplasms (Breast Cancer) 05/2020 - 09/2010
4	Skin Diseases (Skin Disease) 01/2020 - 01/2016
4	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019 - 07/2013
4	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2012
3	Carcinoma (Carcinomatosis) 03/2022 - 06/2012
3	Hepatocellular Carcinoma (Hepatoma) 09/2020 - 02/2010
3	Starvation 07/2007 - 11/2005
2	Atopic Dermatitis (Atopic Eczema) 03/2022 - 01/2013
2	Keratitis 09/2021 - 07/2020
2	Conjunctivitis 09/2021 - 07/2020
2	Carcinogenesis 01/2019 - 01/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2016 - 03/2015
2	Arthritis (Polyarthritis) 11/2015 - 01/2012
2	Hypertrophy 04/2013 - 12/2006
1	Sarcoma (Soft Tissue Sarcoma) 01/2022
1	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 09/2021
1	Dry Eye Syndromes (Dry Eye Syndrome) 09/2021
1	Inflammation (Inflammations) 09/2021
1	Necrosis 01/2021
1	Lung Diseases (Lung Disease) 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 06/2020
1	Skin Neoplasms (Skin Cancer) 01/2020
1	Macular Degeneration (Age-Related Maculopathy) 09/2019

Drug/Important Bio-Agent (IBA)

17	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2009
17	Proteins (Proteins, Gene)FDA Link 05/2020 - 07/2007
9	AntioxidantsIBA 01/2018 - 01/2009
7	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 10/2009
7	FlavonoidsIBA 07/2016 - 01/2009
7	Messenger RNA (mRNA)IBA 09/2015 - 04/2012
6	EnzymesIBA 10/2018 - 01/2011
6	PhloroglucinolIBA 10/2018 - 02/2006
6	ginsenoside M1IBA 12/2013 - 07/2009
6	SaponinsIBA 12/2013 - 07/2009
5	Caspase 3 (Caspase-3)IBA 01/2020 - 07/2013
5	Fluorouracil (Carac)FDA LinkGeneric 04/2018 - 03/2002
4	shikoninIBA 05/2022 - 04/2018
4	CaspasesIBA 05/2022 - 02/2013
4	Caspase 9IBA 01/2020 - 07/2013
4	LuteolinIBA 01/2019 - 06/2013
4	Transcription Factor 3IBA 07/2017 - 04/2012
4	eckolIBA 08/2014 - 11/2005
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 07/2013 - 03/2010
3	Pharmaceutical PreparationsIBA 05/2022 - 06/2016
3	fisetinIBA 01/2022 - 03/2015
3	esculetinIBA 10/2015 - 12/2008
3	Biomarkers (Surrogate Marker)IBA 09/2015 - 08/2012
3	butinIBA 06/2012 - 03/2010
3	8-Hydroxy-2'-DeoxyguanosineIBA 01/2011 - 01/2006
2	Cisplatin (Platino)FDA LinkGeneric 05/2022 - 04/2018
2	NaphthoquinonesIBA 05/2022 - 04/2018
2	Cytochromes c (Cytochrome c)IBA 01/2022 - 01/2020
2	Retinaldehyde (Retinal)IBA 09/2021 - 01/2021
2	Acetylcysteine (Siran)FDA LinkGeneric 01/2021 - 01/2018
2	Particulate MatterIBA 01/2021 - 07/2020
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 05/2020 - 07/2003
2	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 01/2019 - 05/2016
2	Cadherins (E-Cadherin)IBA 04/2018 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 07/2017 - 09/2014
2	Histone Deacetylases (Histone Deacetylase)IBA 07/2017 - 12/2013
2	Matrix Metalloproteinases (MMPs)IBA 11/2015 - 01/2012
2	coumarinIBA 10/2015 - 12/2008
2	Ethanol (Ethyl Alcohol)IBA 01/2015 - 06/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2014 - 03/2012
2	8-hydroxyguanineIBA 01/2013 - 01/2006
2	CatalaseIBA 01/2011 - 07/2007
2	cholest-5-en-3 beta,7 alpha-diolIBA 08/2005 - 03/2002
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 09/2022
1	bis(diazo)benzidine (BDB)IBA 03/2022
1	5-bromo-3,4-dihydroxybenzaldehydeIBA 03/2022
1	Biological ProductsIBA 03/2022
1	SpermidineIBA 09/2021
1	Air Pollutants (Pollutants, Air)IBA 09/2021
1	PolyaminesIBA 09/2021
1	Ophthalmic Solutions (Eye Drops)IBA 09/2021
1	AerosolsIBA 01/2021
1	Retinal Pigments (Pigments, Visual)IBA 01/2021
1	coptisineIBA 01/2021
1	sulforaphaneIBA 09/2020
1	Oxidoreductases (Dehydrogenase)IBA 09/2020
1	Auranofin (Ridaura)FDA Link 09/2020
1	LY2109761IBA 07/2020
1	humaninIBA 06/2020
1	PeroxiredoxinsIBA 01/2020
1	hemistepsinIBA 01/2020
1	SesquiterpenesIBA 01/2020
1	anthraceneIBA 01/2020
1	Mitogen-Activated Protein KinasesIBA 01/2020
1	LactonesIBA 01/2020

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 01/2022 - 03/2002
5	Therapeutics 07/2017 - 03/2008
1	Immunotherapy 01/2022
1	Radiotherapy 01/2022